A complete list of Dr. Lamming’s Publications can be found on Pubmed
Dietary Protein and Amino Acids in Age-Related Disease
Recent publications:
- Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice, Cell Metabolism, 2021
- Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction, Cell Metabolism, 2022
- The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine, Cell Metabolism, 2021
- Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice, Nature Aging, 2021
- Restoration of metabolic health by decreased consumption of branched-chain amino acids, Journal of Physiology, 2018
- Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health, Cell Reports, 2016
Recent reviews:
- When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging, Cell Metabolism, 2023
- Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism, Aging Cell, 2022
- Molecular mechanisms of dietary restriction promoting health and longevity, Nature Revew Mol Cell Bio, 2021
- The regulation of healthspan and lifespan by dietary amino acids, Translational Medicine of Aging, 2021
The Biology of Aging and mTOR
Recent publications:
- Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice, Nature Metabolism, 2021
- Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging, eLife, 2020
- Calorie Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension, Cell Reports, 2019
- Hypothalamic mTORC2 is essential for metabolic health and longevity, Aging Cell, 2019
- Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice, Aging Cell, 2015
Recent reviews:
- The central moTOR of metabolism, Developmental Cell, 2022
- mTOR: The Grand ConducTOR of Metabolism and Aging, Cell Metabolism, 2016
Recent protocols:
- A toolbox for the longitudinal assessment of healthspan in aging mice, Nature Protocols, 2020
Rapamycin and rapalogs
Recent publications:
- Blazing a trail for the clinical use of rapamycin as a geroprotecTOR, Geroscience, 2023
- A novel rapamycin analog is highly selective for mTORC1 in vivo, Nature Communications, 2019
- Rapamycin blocks induction of the thermogenic program in white adipose tissue, Diabetes, 2016
- Intermittent administration of rapamycin extends the lifespan of female C57BL/6J mice, JGBS, 2016
- Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system, Aging Cell, 2015
Recent reviews:
- Targeting the biology of aging with mTOR inhibitors, Nature Aging, 2023
- Next generation strategies for geroprotection via mTORC1 inhibition, JGBS, 2019
- Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island, JGBS, 2016
Older selected publications:
- Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan, Aging Cell, 2014
- Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 2014; 28(1):300-15. doi: 10.1096/fj.13-237743.(PubMed Link) (PDF)
- Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013; 12(4):712-8. doi: 10.1111/acel.12097.(PubMed Link) (PDF)
- Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335(6076):1638-43. Epub 2012/03/31. doi: 10.1126/science.1215135.(PubMed Link) (PDF)