Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.
- Dietary Branched-Chain Amino Acids in Aging and Age-Related Disease
- Dietary Macronutrients in Healthy Aging
- mTOR and Rapalogs
The Lamming lab is supported in part by the NIH National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Other recent sources of support include the American Federation For Aging Research, the Glenn Foundation for Medical Research, the Progeria Research Foundation, and the Wisconsin Partnership Program.
Postdoctoral, Ph.D. students, M.D. students and undergraduates interested in pursuing research in the Lamming lab should contact Dr. Lamming directly at dlamming@medicine.wisc.edu.
Isoleucine is an essential amino acid which, in excess, counters the health benefits of the mTOR longevity pathway. The @LammingLab is reporting that an isoleucine-restricted diet extends the lifespan of mice by 33% 👏 @Cell_Metabolism pic.twitter.com/rGKHVCgjPI
— David Sinclair (@davidasinclair) November 9, 2023
Study from Lamming lab shows that strength training may reduce risks of a high-protein diet@LammingLab
— Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺 (@agingdoc1) October 28, 2023
🔗https://t.co/pEX1nbOljM | @uw_medicine @uwsmph https://t.co/DBJHYDCPve pic.twitter.com/H65gbDNX1R
A delight to write this piece - which brings together to-the-minute information regarding ongoing, pending, and planned human clinical trials of rapamycin for the first time - with @maml_UWMadison! https://t.co/af82M9bV7w
— Lamming Lab (@LammingLab) October 6, 2023
Congratulations to @LammingLab graduate student Shelly Sonsalla for receiving the UW Institute on Aging New Investigator Award! pic.twitter.com/ELweojO95C
— Lamming Lab (@LammingLab) September 28, 2023
Arrived in the Netherlands and heading to G-JAM to present our labs work. Looking forward to seeing colleagues I have not seen in person in far too long! https://t.co/V83hMIahDP
— Lamming Lab (@LammingLab) September 27, 2023
Great talk by @garacreen on her published and ongoing research! https://t.co/TlQ50KuO44 pic.twitter.com/WmrxAogVyl
— Lamming Lab (@LammingLab) September 7, 2023
Looking forward today to speaking (along with lab member @garacreen) at the OFAS-@NIHAging Joint Workshop on Optimizing Dietary Amino Acid Intake to Improve Human Health & Reduce the Burden of Age-Related Disease! https://t.co/sRzlNNG75P
— Lamming Lab (@LammingLab) September 7, 2023
Congratulations to graduate student @mariahcalubag, whose paper on "FGF21 Has a Sex-Specific Role in Calorie-Restriction-Induced Beiging of White Adipose Tissue in Mice" is now offically out in the first ever issue of Aging Biology! https://t.co/i5u0P7mm6Q pic.twitter.com/MJ3hrTxM0X
— Lamming Lab (@LammingLab) July 5, 2023
Looking forward to this meeting! https://t.co/rlcSftz1p5
— Lamming Lab (@LammingLab) May 22, 2023
Rapamycin week continues with Revenge of the #sirolimus - looking forward to kicking this total off with @maml_UWMadison ! https://t.co/hG64h2dWCx
— Lamming Lab (@LammingLab) May 5, 2023
Congrats to lab alumni @pak_heidi who will be presenting on some completely new exciting work from the conclusion of her time in the @LammingLab! https://t.co/hOrbmobeTT
— Lamming Lab (@LammingLab) May 4, 2023
Madison PIs ready for #MAC2023! @AgingMidwest @AndersonRozalyn @maml_UWMadison @uw_medicine pic.twitter.com/FYmbTQWXAz
— Lamming Lab (@LammingLab) May 1, 2023
May the #rapamycin be with you! Pleased to be able to announce our new review on "Targeting the biology of aging with #mTOR inhibitors" with @MannickJoan now available at @NatureAging. Free-to-read link now available at https://t.co/8cdajcZjCF pic.twitter.com/mMIxCWAx0Y
— Lamming Lab (@LammingLab) May 4, 2023
Glad this review is now out. A free-to-read link for those without access to the journal is available here: https://t.co/G9guvIrmcr https://t.co/BTtMMi5CrX
— Lamming Lab (@LammingLab) April 7, 2023