Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.
Dietary Branched-Chain Amino Acids in Aging and Age-Related Disease
Dietary Macronutrients in Healthy Aging
mTOR and Rapalogs
The Lamming lab is supported in part by the NIH National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Other recent sources of support include the American Federation For Aging Research, the Glenn Foundation for Medical Research, the Progeria Research Foundation, and the Wisconsin Partnership Program.
Postdoctoral, Ph.D. students, M.D. students and undergraduates interested in pursuing research in the Lamming lab should contact Dr. Lamming directly at dlamming@medicine.wisc.edu.
I am pleased to report our new manuscript from graduate student @mariahcalubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! pic.twitter.com/zrrvThpTgg
— Lamming Lab (@LammingLab) July 29, 2025
Congratulations to the recipients of the DOM Trainee Outstanding Research Awards! These awards recognize significant research contributions made during residency and fellowship training.
— University of Wisconsin Department of Medicine (@uw_medicine) July 18, 2025
(continued in 🧵)
Read more: https://t.co/kKpHsdGmfA pic.twitter.com/E7q1rErSRV
Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: Dietary lipids are largely deposited in skin and rapidly affect insulating properties (link in comments) pic.twitter.com/T0Zr4uRR1E
— Lamming Lab (@LammingLab) May 16, 2025
It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony @christinewhelan who gave a highly inspiring and impactful address! pic.twitter.com/hOaIZmMvEY
— Lamming Lab (@LammingLab) May 10, 2025
With the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below. pic.twitter.com/oYfNq2hrkz
— Lamming Lab (@LammingLab) December 31, 2024
Glad this paper is finally out! Here first author @iCCup_Spec shows the power of protein and isoleucine restriction as late-life interventions, showing many positive benefits to health as well as positive and perhaps even rejuvenating benefits at the molecular level. https://t.co/OQVPtsfcHY
— Lamming Lab (@LammingLab) November 27, 2024
A slightly tardy but huge congratulations to lab graduate student @baileyknopf who won the UW Institute on Aging New Investigator Award for Biological/Biomedical Research! pic.twitter.com/k1H2soHglk
— Lamming Lab (@LammingLab) September 20, 2024
📢New in GeroScience by Springer Nature
— GeroScience (@GeroScienceAGE) September 23, 2024
Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease by Michelle M. Sonsalla (@mmsonsalla) & Dudley W. Lamming et al.https://t.co/6b410W9PSg#AlzheimersDisease… https://t.co/iA3hd41Nte pic.twitter.com/q1tkwaf5Wo
Quite the week for publications in the lab - check out grad student @mariahcalubag new review in @Cell_Metabolism "A nutrigeroscience approach: Dietary macronutrients and cellular senescence" https://t.co/IiI8N2EnmY pic.twitter.com/41iv24IX2H
— Lamming Lab (@LammingLab) August 22, 2024
Proud to announce former grad student @pak_heidi's publication, "Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions" - or alternatively "Why don't we understand CR after ~100 years of study?" https://t.co/6JoPvLSJ6S
— Lamming Lab (@LammingLab) August 21, 2024
Glad to have been able to help with this landmark study! https://t.co/XrJEzhk0DB
— Lamming Lab (@LammingLab) July 11, 2024
Pleased to announce the publication of @RejiBabygirija's long-awaited paper, "Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease" - also reverses metabolic deficits and improves cognition https://t.co/1KEKz8Sjdt
— Lamming Lab (@LammingLab) June 18, 2024
Arise, Dr. Michaela of house Trautman, a knight of the Lamming Lab! We are proud of you @michaelamRD and glad your family could join us on this momentous day! pic.twitter.com/yxgEg8JbRu
— Lamming Lab (@LammingLab) June 10, 2024
Amazing talk from our very own Yang Yeh @iCCup_Spec on his awesome work on isoleucine restriction and rapamycin at the @americanaging #AGE2024 meeting in Madison. @LammingLab #dietarycontext pic.twitter.com/PR9JmT4sSC
— Cara Green (@garacreen) June 4, 2024
Our paper describing two new summary statistics, FAMY and GRAIL, enabling the quantification of healthspan in mice, is now out in Geroscience! https://t.co/ozP3eLgDKM This is a refined version ready to be used in your work (Those w/o journal access see https://t.co/FJXFcOOBp0). https://t.co/1k5qbWzBmG
— Lamming Lab (@LammingLab) May 17, 2024
Congratulations to Yang Yeh, PhD, research associate, Endocrinology, Diabetes and Metabolism on receiving a Wisconsin Initiative for Science Literacy (WISL) Award for Communicating Postdoctoral Research to the Public. pic.twitter.com/lkJtlTuTIM
— University of Wisconsin Department of Medicine (@uw_medicine) March 26, 2024
Congratulations to Dr. Dudley Lamming (@LammingLab) on being named the next Department of Medicine Vice Chair for Biomedical Research!
— University of Wisconsin Department of Medicine (@uw_medicine) March 18, 2024
Learn more: https://t.co/OvXwTGZl56 pic.twitter.com/D6yVqhIQEg
Yesterday was not just our annual lab retreat (held jointly with @JudithSimcox lab this year), but the Lamming Decennial & Simcox Quinquennial Celebration! It is so hard to believe 10 years have gone by since that frigid polar vortex day I arrived at UW-Madison to open my lab.
— Lamming Lab (@LammingLab) January 18, 2024
With the end of the year upon us, it's time for the 2023 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below.
— Lamming Lab (@LammingLab) December 27, 2023
Isoleucine is an essential amino acid which, in excess, counters the health benefits of the mTOR longevity pathway. The @LammingLab is reporting that an isoleucine-restricted diet extends the lifespan of mice by 33% 👏 @Cell_Metabolism pic.twitter.com/rGKHVCgjPI
— David Sinclair (@davidasinclair) November 9, 2023
Study from Lamming lab shows that strength training may reduce risks of a high-protein diet@LammingLab
— Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM (@agingdoc1) October 28, 2023
🔗https://t.co/pEX1nbOljM | @uw_medicine @uwsmph https://t.co/DBJHYDCPve pic.twitter.com/H65gbDNX1R
A delight to write this piece - which brings together to-the-minute information regarding ongoing, pending, and planned human clinical trials of rapamycin for the first time - with @maml_UWMadison! https://t.co/af82M9bV7w
— Lamming Lab (@LammingLab) October 6, 2023
Congratulations to @LammingLab graduate student Shelly Sonsalla for receiving the UW Institute on Aging New Investigator Award! pic.twitter.com/ELweojO95C
— Lamming Lab (@LammingLab) September 28, 2023
Arrived in the Netherlands and heading to G-JAM to present our labs work. Looking forward to seeing colleagues I have not seen in person in far too long! https://t.co/V83hMIahDP
— Lamming Lab (@LammingLab) September 27, 2023
Great talk by @garacreen on her published and ongoing research! https://t.co/TlQ50KuO44 pic.twitter.com/WmrxAogVyl
— Lamming Lab (@LammingLab) September 7, 2023
Looking forward today to speaking (along with lab member @garacreen) at the OFAS-@NIHAging Joint Workshop on Optimizing Dietary Amino Acid Intake to Improve Human Health & Reduce the Burden of Age-Related Disease! https://t.co/sRzlNNG75P
— Lamming Lab (@LammingLab) September 7, 2023
Congratulations to graduate student @mariahcalubag, whose paper on "FGF21 Has a Sex-Specific Role in Calorie-Restriction-Induced Beiging of White Adipose Tissue in Mice" is now offically out in the first ever issue of Aging Biology! https://t.co/i5u0P7mm6Q pic.twitter.com/MJ3hrTxM0X
— Lamming Lab (@LammingLab) July 5, 2023
Looking forward to this meeting! https://t.co/rlcSftz1p5
— Lamming Lab (@LammingLab) May 22, 2023
Rapamycin week continues with Revenge of the #sirolimus - looking forward to kicking this total off with @maml_UWMadison ! https://t.co/hG64h2dWCx
— Lamming Lab (@LammingLab) May 5, 2023
Congrats to lab alumni @pak_heidi who will be presenting on some completely new exciting work from the conclusion of her time in the @LammingLab! https://t.co/hOrbmobeTT
— Lamming Lab (@LammingLab) May 4, 2023
Madison PIs ready for #MAC2023! @AgingMidwest @AndersonRozalyn @maml_UWMadison @uw_medicine pic.twitter.com/FYmbTQWXAz
— Lamming Lab (@LammingLab) May 1, 2023
May the #rapamycin be with you! Pleased to be able to announce our new review on "Targeting the biology of aging with #mTOR inhibitors" with @MannickJoan now available at @NatureAging. Free-to-read link now available at https://t.co/8cdajcZjCF pic.twitter.com/mMIxCWAx0Y
— Lamming Lab (@LammingLab) May 4, 2023
Glad this review is now out. A free-to-read link for those without access to the journal is available here: https://t.co/G9guvIrmcr https://t.co/BTtMMi5CrX
— Lamming Lab (@LammingLab) April 7, 2023